Like nurses nationwide, the ANA Enterprise adapted as the COVID-19 pandemic waxed and waned. We advocated relentlessly on behalf of nurses and their work environment challenges—physical safety, optimal staffing, and mental health and well-being support. Along with our constituent and state nurses associations and stakeholder partners, we pushed to remove federal and state barriers to practice, and we offered rich, thought-provoking content to inspire nurses’ design-thinking while staying abreast of evolving practices. We convened world-class subject matter experts to educate nurses on a broad range of contemporary topics. When nurses and the nursing profession were assailed, we advocated for Just Culture in examining patient care errors, and we consistently called for education and resources to support the public’s health.